MOTS-c Peptide Stability: How Long Does It Really Last After Reconstitution?
MOTS-c Peptide Stability: How Long Does It Really Last After Reconstitution?
There is much speculation about how long MOTS-c peptide remains stable after reconstitution. Some claim it degrades within hours, making it ineffective the next day. However, recent scientific studies suggest otherwise, indicating that MOTS-c has greater stability than previously assumed.
What the Research Shows
Studies examining MOTS-c stability have found that when stored at 2–8°C in bacteriostatic water, the peptide retains significant structural integrity for up to 2–4 weeks post-reconstitution. This is consistent with the stability profile of similar mitochondria-derived peptides.
Factors Affecting Stability
- Storage temperature: 2–8°C is optimal for reconstituted MOTS-c
- pH: Neutral to slightly alkaline pH (6.5–7.5) is preferred
- Light exposure: Store away from direct light
- Freeze-thaw cycles: Minimise by aliquoting before first use
Recommendations for Researchers
We recommend reconstituting MOTS-c in bacteriostatic water, aliquoting into single-use portions, and storing at 2–8°C. Use within 3–4 weeks of reconstitution for best results in research settings.
